Stromectol 12mg, 3mg, 6mg
Global Impact of Stromectol
Since its FDA approval in 1996, Stromectol has treated over 300 million patients worldwide. Key milestones:
- 1998: WHO includes ivermectin in Onchocerciasis Elimination Program
- 2012: 1 billion doses distributed via mass drug administration
- 2021: 92% efficacy against strongyloidiasis confirmed in phase IV trials
Targeted Parasitic Infections
Nematode Infections
- Strongyloidiasis - Intestinal threadworms affecting 600M people globally
- Onchocerciasis - Second-leading infectious cause of blindness
Arthropod Infestations
- Crusted Scabies - 10,000+ mites per patient in HIV+ individuals
- Pediculosis - Resistant head lice strains (knockdown resistance gene kdr)
Neuropharmacological Action
Ivermectin's unique molecular targets:
| Parasite Type | Target Receptor | Outcome |
|---|---|---|
| Nematodes | Glutamate-gated Cl⁻ channels | Muscle paralysis |
| Arthropods | GABA receptors | Neurotransmission block |
Precision Dosing Protocols
Strongyloidiasis Treatment
| Patient Weight | Stromectol 3mg Tablets | Total Dose |
|---|---|---|
| 15-24 kg | 3 tablets | 9 mg |
| 25-50 kg | 4 tablets | 12 mg |
Scabies Management
- Day 1: 200 mcg/kg
- Day 8: Repeat dose
- Day 30: Follow-up skin scraping
Adverse Event Management
Common Reactions
- Mazzotti reaction (fever, pruritus)
- Transient eosinophilia (+15% from baseline)
Contraindications
- Loa loa coinfection (risk of encephalopathy)
- Concurrent warfarin therapy (monitor INR)
2023 Clinical Findings
- Journal of Infectious Diseases: Stromectol reduces Strongyloides larval output by 99.2% at 14 days post-treatment
- Lancet Microbe: Emerging resistance in Sarcoptes scabiei (India, Australia)
Frequently Asked Questions
How long does Stromectol stay in the system?
Half-life: 18 hours. Detectable in plasma for 72 hours post-dose.
Can I breastfeed after taking Stromectol?
Wait 72 hours - drug excreted in breast milk (0.5% maternal dose).
Scientific References
- WHO Model Prescribing Information: Antiparasitic Drugs (2022)
- New England Journal of Medicine: Ivermectin vs Albendazole Trial (2021)
